Layer thickness

Are there any downsides/consequences to look for when printing at a layer thickness of .025?
Any settings like z lift etc that need changing?

0.025 layer thickness is perfect for very fine details, but it can significantly increase printing time.
For models with less intricate surface, you can use higher layer thickness.
No need to change Z-lift distance, as its default value is adjusted to the layer. However, if a model has a lot of fine details, you can decrease platform lift speed.